October 28, 2026
NOT ALL CLEANSERS ARE CREATED EQUAL
Cleansing may seem like the simplest step in your skincare routine, but how you cleanse can make a significant difference in how your skin...
Harvard & Cornell educated M.D., Ph.D.
Clinically proven. Visibly transformative.
High-potency, bio-identical formulations engineered to visibly change your skin's architecture, firmness and glow — measured by independent labs, not by opinion.
Over 20 million products sold worldwide
198% more skin surface lipids after 15 minutes — instrumental clinical study
Best sellers
The four she is asked about most
In their words
Best skincare! I have switched my skincare. I’m 64 but am told I look 40!
NurseMaryAnnHydroShield® Hydrating Dream CreamThis product size is perfect for weeks of travel — a must have when skin care is important during humid weather, resistance to dry skin!
Denise Skin Care UserHydroShield® Ultra Moisturizing Face SerumI’ve used the under eye cream twice a day for several years. I love how it keeps me wrinkle free!
BevBFirming Facial Collagen Eye CreamStart with the concern
What would you change first?
Independent clinical study
Don't moisturize the wrinkle. Rebuild the barrier.
As skin ages, its own lipids decline and moisture escapes. HydroShield® Technology supplies skin-identical lipids, ceramides and essential fatty acids so the barrier works at a younger level again. Measured by instrument, not by opinion.
198%
increase in skin surface lipids after 15 minutes
100%
of subjects: skin has a radiant glow
97.7%
lines, wrinkles and crepiness around the eye visibly reduced
Instrumental and consumer-perception results, HydroShield® Ultra Moisturizing Face Serum.
Before & after
The same face, weeks apart.
These are the photographs from the clinical testing of each formula — not retouched stand-ins. The number under each one is what that study measured.
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198% more skin surface lipids after 15 minutes
HydroShield® Ultra Moisturizing Face Serum
Instrumental clinical study, 15 minutes
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29% measurable increase in skin firmness and tightness
HydroShield® Hydrating Dream Cream
Independent expert grading study, 21 days
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90% skin was more toned and lifted
Advanced Firming Facial Pads
Independent consumer study, 21 days
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From the clinical testing of each product. Individual results vary.
The science of skincare
A doctor formulated this, not a marketing team.
Adrienne Denese, M.D., Ph.D. — Harvard and Cornell trained, and one of the first physicians to specialise in anti-aging medicine. Every formula leaves SkinScience Labs with the highest percentage of active, bio-identical ingredients it can carry. Over 20 million products sold worldwide.
“I formulate for results, not for hope.”
Adrienne Denese, M.D., Ph.D.
Dr. Denese Simple Steps skin care program
Four steps. Morning and night.
Build the routine in the order the skin actually uses it. Add one step at a time — each works on its own.
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01
Cleanse & Tone
Remove the day without stripping the barrier, then rebalance so the next step can absorb.
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02
Exfoliate
Clear the dead surface layer so texture softens and everything after it works harder.
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03
Treat
The active step. Skin-identical lipids where lines and crepiness show first.
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04
Seal & Protect
Lock the work in overnight — and shield it from the light that undoes it by day.
Complete the routine
Award Winning Power Trio
Exfoliate, rebuild the lipid barrier, then seal it overnight. The three steps that do the most work, in the order the skin uses them.
- 1 Advanced Firming Facial PadsNightly exfoliation. 90% of users saw skin more toned and lifted in 21 days (independent consumer study).
- 2 HydroShield® Ultra Moisturizing Face SerumBio-identical lipids. 198% increase in skin lipids in just 15 minutes.
- 3 HydroShield® Hydrating Dream CreamSeals the first two steps in overnight. 100% of subjects: appearance of lines dramatically improved (21 days).
$79$127
Save 38%
Shop the trioFree U.S. shipping over $75 · 30-day money-back guarantee
Sent in by customers
Their own photos, their own words
Every picture here was uploaded by a customer with her review. The words are hers too — shortened at a full stop where a card ran long, never rewritten.
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I use almost all of Dr Denese products. I am 78 Years old but friends and family are amazed at my complexion; like a 50 year young lady
Kathleen C Wrinkle Eraser PM Retinol Stick 0.5 oz -
Best skincare! I have switched my skincare. I’m 64 but am told I look 40!
NurseMaryAnn HydroShield® Hydrating Dream Cream -
The laugh lines are gone except when I smile big and disappears when I stop smiling. I love that my eyes feel wide open like they used to be. I am almost 78 years old.
Sis1 HydroShield Eye Emulsion with Exosome -
I’ve used the under eye cream twice a day for several years. I love how it keeps me wrinkle free!
BevB Firming Facial Collagen Eye Cream -
This is my 2nd purchase! I use this both day and night with my Hydrating Dream Cream! It has visably improved my neck wrinkles.
Heather, age 70! Triple Strength Wrinkle Smoother Advanced Treatment -
This product size is perfect for weeks of travel, a “must have” when skin care is important during humid weather, resistance to dry skin!
Denise Skin Care User HydroShield® Ultra Moisturizing Face Serum -
I have started using this immediately and noticed a big difference in my lines on my chin and around my mouth!! And I didn’t have to use a lot of the product either to achieve that result.
MissGina67 Wrinkle Lost Line Reducer -
My skin looks really bright and firm, and feels smooth immediately after use. I have slightly sensitive skin and it didn’t irritate me at all.
RebeccaS Collagen Firming Peel Off Mask -
I’ve been using this face paste and peel drops for a few weeks now and my face feels so smooth! I can’t stop feeling my face!
Tan88 Peel & Glow Rx Vitamin C Face Paste & AHA Peel Drops Set -
I use it every day and my lips love it and I look better and younger!
Verified customer MegaLips Peptide Lip Oil 0.2 oz -
My face feels so soft after using and it really does look brighter too!
Persnickerdy Peel & Glow Rx Vitamin C Face Paste & AHA Peel Drops Set -
So I’m 55, I have fine lines, puffy eyes, dark circles. I see some improvement when I use it in my puffiness. For what improvement I have seen in the little time I’ve used it, I will definitely be using it every day.
Strwbrrydanish Wrinkle Lost Line Reducer
Photographs and reviews submitted by customers and published with their permission. Individual results vary.
New arrivals
The newest formulas from SkinScience Labs
From SkinScience Labs
Read before you buy
How the formulas work, what the studies measured, and how to build a routine that holds up.
October 21, 2026
WHY IS THE NECK SO CHALLENGING TO TREAT?
Unlike facial aging, the visible changes we see in the neck are rarely caused by just one factor. The skin, underlying support structures and...
October 14, 2026
Your Lymphatic System: The Unsung Hero of Daily Detox
SkinScience 101 with Dr. Adrienne Denese, MD PhD "Knowledge is the first step to your most beautiful skin. Every Wednesday, I’m opening my lab...
Before you buy
The questions we get asked most
If something here is still unclear, the team answers the phone.
How soon will I see something?
Skin needs weeks, not days. Hydration is measurable within 15 minutes, but the studies behind these formulas ran 21 to 42 days for lines, firmness and texture. Give a product four weeks of daily use before you judge it — and use the whole jar. If you don't see results, we refund you.
In which order do I use everything?
In the evening: cleanse and tone, exfoliate, treat, build the lipid barrier, seal. In the morning: build the barrier, then protect with SPF. Add one step at a time — each one works on its own, and the programme page walks through all of them.
How does Auto-replenish work?
It is pay as you go: you are charged for each delivery as it ships, never up front for the ones after it. You choose the rhythm when you order, and the saving grows with how often it ships — up to 15%. The intervals and the exact saving differ by product and are shown on that product's page; not every product offers a subscription.
To change, pause or stop a delivery, write to askthedr@drdenese.com or call 866-642-3754, Monday to Friday, 9am–5pm ET.
What does shipping cost?
Shipping within the U.S. is free on orders over $75. Below that, standard delivery is $6.95 and two-day delivery is $24. Orders placed before 1pm Eastern usually ship the same day. Rates outside the U.S. are shown at checkout and in our shipping policy.
What if it doesn't work for me?
Every order carries a 30-day money-back guarantee. Use the whole jar — if you don't see results, we refund you, and you do not need to send the empty jar back. The full terms are in our refund policy.
Use the whole jar.
If you don't see results, we refund you. 30 days, no return of the empty jar required.