Dr. Denese HydroShield Face Emulsion with Exosome
  • Doctor developed
  • Clinically tested
  • PETA cruelty free
  • Made in USA

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HydroShield Face Emulsion with Exosome


HydroShield Face Emulsion with Exosomes targets the top causes of aging skin—moisture loss, dehydration, and depleted skin lipids. Powered by AcquaCell Technology, ceramides, squalene, and Sodium PCA, it deeply hydrates and helps restore a youthful look. Plant-based exosomes signal skin to behave younger, while clinical studies show up to 57% reduction in moisture loss and a 151% increase in hydration within 30 minutes. Wake up to smoother, plumper, more radiant skin. Use nightly after serum.

74%
more skin moisture within 30 minutes
41%
less water loss through the skin
96%
said dry lines are visibly reduced

Two clinical studies and a consumer perception survey, 28 days of twice-daily use. See the studies

size — 3.4 oz
3.4 oz $99$29.12 / oz.
Purchase options
$99
30-Day Money-Back Guarantee
Use the whole jar. If you don't see results, we refund you.

Product details

Why it is different

HydroShield Face Emulsion with Exosomes is a powerful nighttime moisturizer designed to target three primary signs of skin aging: trans epidermal water loss, dehydration, and the depletion of essential skin-replenishing components. This luxurious formula helps restore skin’s youthful vitality and suppleness by delivering advanced hydration and cutting-edge anti-aging technology.

Key Benefits:

  • Formulated with AcquaCell Technology—a blend of watermelon, apple, and lentil extracts—this emulsion helps your skin retain moisture and visibly improves plumpness and elasticity.
  • Enriched with Sodium PCA, known as the “hydration molecule of youth,” alongside ceramides and squalene to mimic and support your skin's natural barrier.
  • Features a plant-based Exosome complex, one of the most revolutionary advancements in skincare. These natural messengers help signal skin cells to behave more youthfully, improving texture and resilience.
  • – Reduces trans epidermal water loss by up to 57%
    – Increases skin’s moisture levels by an average of 74%, with results up to 151% within 30 minutes
  • Wake up to skin that feels noticeably softer, smoother, and more hydrated. Fine lines and wrinkles appear diminished, and skin looks refreshed and rejuvenated.

How to Use:
Apply in the morning after your HydroShield Serum and before your SPF 40 Defense Day Cream.
At night, use as your last step after your HydroShield Face Serum.

Clinical studies

The results, by the numbers

Extensive Trans epidermal water loss leaves your skin dry, dehydrated and older looking then it should. Our cream significantly reduces trans epidermal water loss. We conducted a clinical study to prove this point,  which showed a dramatic 41% with up to 57% reduction is trans epidermal water loss.

A second clinical study proved that  our HydroShield Face Emulsion  increased skin moisture content on average by 74% and up to a 151% within 30 minutes of application.

In a consumer perception survey after 28 days of twice daily use;

93% of participants reported dry wrinkles are visibly reduced.

96% of participants reported dry lines are visibly reduced.

100% of participants reported skin feels more supple and soft.

93% of participants reported skin appears more plump.

96% of participants reported skin looks and feels younger and more refined.

96% of participants skin feels immediately hydrated.

96% of participants reported skin feels hydrated hours after application

96% of participants reported skin feels hydrated and moisturized throughout the day.

How to use

How to use

Apply in the morning after your HydroShield Serum and before your SPF 40 Defense Day Cream. At night, use as your last step after your HydroShield Face Serum.

Ingredients

What is inside

Water (Aqua), Butyrospermum Parkii (Shea Butter), Squalane, Butylene Glycol, Steareth-2, Di-C12-15 Alkyl Fumarate, Cetearyl Alcohol, Sodium Hyaluronate, Steareth-21, Methyl Glucose Sesquistearate, Beeswax, Stearyl Dimethicone, Sodium Stearoyl Glutamate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Cyclopentasiloxane, Dimethicone, Polysilicone-11, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Dimethiconol, Mica, Titanium Dioxide, Iron Oxides, Arginine, Dipotassium Glycyrrhizate, C12-15 Alkyl Benzoate, Tribehenin, Ceramide NG, PEG-10 Phytosterol, Palmitoyl Hexapeptide-12, Adenosine, Tocopheryl Acetate, Citrullus Vulgaris (Watermelon) Fruit Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Sodium Lactate, Sodium PCA, Citrus Reticulata (Tangerine) Fruit Extract, Citrus Reticulata (Tangerine) Fruit Juice Vesicles, 1,2-Hexanediol, Alcohol, Foeniculum Vulgare (Fennel) Fruit Extract, Humulus Lupulus (Hops) Extract, Melissa Officinalis Leaf Extract, Viscum Album (Mistletoe) Leaf Extract, Chamomilla Recutita (Matricaria) Flower Extract, Achillea Millefolium Extract, Urea, Allantoin, Betaine, Sorbitol, Glycine, Alanine, Proline, Serine, Threonine, Arginine, Lysine, Glutamic Acid,  Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Carbomer, Polysorbate 20, Polysorbate 60, Xanthan Gum, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

 

  • Always Doctor developed
  • Always Clinically tested
  • Always Visible results
  • Always High percentages of actives
  • Always PETA cruelty free
  • Always Manufactured in USA

Sent in by customers

Their own photos, their own words

Photographs customers uploaded with their reviews, across the range. The words are theirs — shortened at a full stop where a card ran long, never rewritten.

Photographs and reviews submitted by customers and published with their permission. Individual results vary.

Dr. Denese Simple Steps skin care program

Where this product fits in your routine

Simple morning routine

  1. 1
    Build Lipid Barrier

    Keeps water from leaving the skin. Hydrated skin is healthy skin.

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  2. 2
    Protect & Correct

    SPF 30 or 40 — rain or shine, summer and winter. 90% of skin aging is caused by daily sun exposure.

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Simple evening routine

  1. 1
    Cleanse & Tone

    A pH-balanced, non-drying cleanser — skip the soap — then a toner for what it missed.

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  2. 2
    Exfoliate & Purify

    Stimulates cellular turnover and lets the actives that follow reach their destination.

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  3. 3
    Stimulate Cellular Performance

    A thin, water-consistency serum that encourages the skin's own collagen building.

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  4. 4
    Build Lipid Barrier

    Lipid-based serum with ceramides, retinol, antioxidants and essential fatty acids.

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  5. 5
    Seal & Maintain

    Finish with your night cream to seal the work in.

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Complete the routine

Award Winning Power Trio

The Firming Facial Pads, the HydroShield® Serum and the Hydrating Dream Cream as one starter kit.

$79$127
Shop the trio

Reviews

What customers say

A doctor formulated this, not a marketing team.

Who made it

A doctor formulated this, not a marketing team.

Adrienne Denese, M.D., Ph.D. — Harvard and Cornell trained, and one of the first physicians to specialise in anti-aging medicine. Every formula leaves SkinScience Labs with the highest percentage of active, bio-identical ingredients it can carry. Over 20 million products sold worldwide.

“I formulate for results, not for hope.”

Adrienne Denese, M.D., Ph.D.