She thought she was stuck with her deep lines...
...until she saw her face 15 minutes after applying HydroShield.
Look at the photo on the left. This isn't months of work. This is the power of hydration in just a quarter of an hour.
She never stopped using it.
It has been many years now. Few women realize that many dry lines and wrinkles are REVERSIBLE to a clearly visible extent—but only with the right tool.
That tool is HydroShield. Based on 6.1 million repeat purchases, we think you may never stop using it either.
Voted #1 Anti-Aging Serum at QVC
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6.1 Million Sold
Millions of repeat purchases mean we must be doing something right.
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Harvard & Cornell Trained
Developed by Dr. Adrienne Denese, a medical doctor committed to verified Clean Beauty.
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198% Lipid Increase
Independent clinical study showing massive hydration boost in 15 minutes.
A Hydrating Superpower
HydroShield pumps hydration into the skin, locks it in, and plumps your skin from within.
Dry lines and wrinkles do not have a chance to survive. They vanish from view.
This is NOT a short-term fix. It gets better every time.
Why does it work? It speaks your skin's language.
As always, it is all about the science.
The key ingredients in HydroShield are lipids that are virtually identical to your own skin’s lipids. At age 25, you had plenty of these. Now? Not so much.
Dr. Denese is giving you back the lipids you used to have in your twenties. Because the molecules are identical, your skin recognizes them and drinks them in. Nothing else can match that.
198% Increase in Skin Lipids
We conducted an Independent Third Party Clinical Study. The result? A 198% increase in skin lipids in just 15 minutes.
Have you ever seen a measured clinical finding at this scale?
Most of us have not. The proven increase translates into such intense rehydration that dry lines simply vanish from view.
Stop needing filters to feel confident.
Most of you never experienced such intense hydration and clearly visible results, not even with the most expensive creams.
It is a feeling that you cannot wait to see your face in the mirror again because you simply can no longer find that forehead line you used to hate.
Your lines are reversible. But only with the right tool. Get HydroShield now.
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I have been using this serum for many years and it remains for me the best! I use it both morning and in the evening for my entire face. It goes on easily absorbs well, and dries after a few minutes. (I find something else to do while waiting the few minutes before I put makeup on in the morning). My skin has always been on the dry side so it really “drinks up” this product. I found this serum well over 10 years ago and while I have periodically tried other brands, I have always returned to this serum. I cannot say enough about how it has been my “go to” skin care moisturizer!! I never wrote a review before but decided it was time!!!
"Tried & True" - Anne H.
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This Is by far One of my favorite products by Dr Denese. I’ve been using it now for about 25 years and it absolutely is a staple In my skincare routine (Which is 100% of Skin science products by Dr Denese). I use it twice a day, once in the morning and again at night. It goes on like butter and my skin sucks it up. The ingredients, as in all of her Anti-aging products, are the best. Please do your research into what you’re putting on your skin, Especially if you want the best quality with the best results. I am an avid Dr Denese fan, She is my hero! Please check out her credentials as she is the pioneer of anti-aging skin care. I promise you you won’t regret using these products. ❤️
"Will not live without!" - Robin D.
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I was introduced to this product by one of my previous customers, Steve, and I have to say this product is absolutely phenomenal. Having dry skin, I’ve searched for several hydrating products, but nothing actually seemed to be working. After trying Dr. Denese’s facial serum, it has changed my life! It moisturizes intensively without giving you that oily or greasy feeling. This is an absolute must try/have, will have your skin feeling like a million bucks! Will be using this product for the rest of my life — already recommended to family & friends who have purchased as well! A big thank you to Steve for introducing me to this product and a huge thank you to Dr. Denese for creating this gem!
"Five Star Product!" - Nikki M.
Dr. Denese
Dr. Denese HydroShield® Ultra Moisturizing Face Serum

So what is Hydroshield?
HydroShield is a hydrating superpower that pumps hydration into the skin, locks in hydration, holds onto hydration and plumps up your skin from within. Dry lines and wrinkles do not have a chance to survive the onslaught of HydroShield, they vanish from view. HydroShield is NOT a short-term fix, it gets better every time
HydroShield is immensely popular for a reason. Voted the #1 Anti-Aging Serum at QVC for the last three years in a row, it has generated over 6.1 million repeat purchases—proof that we must be doing something right. This clinically tested and proven formula was developed by Dr. Adrienne Denese, a Harvard and Cornell-trained medical doctor. Furthermore, it is Verified Clean Beauty, a standard that is deeply important to our founder.
How can we prove that HydroShield performs?
We asked the same question so we conducted an Independent Third Party Clinical, Instrumental Study that found a
198% increase in skin lipids in 15 minutes time.
Have you ever seen a measured clinical finding at this scale? Most of us have not. No wonder it works so well.